A Guaninine Nucleotide Exchange Factor Is a Component of the Meiotic Spindle Pole Body in Schizosaccharomyces pombe

摘要

Spo13 is a sporulation-specific subunit of the Schizosaccharomyces pombe spindle pole body. We show that Spo13 acts specifically as an exchange factor for the Rab GTPase Ypt2 and that this activity is essential for spore formation. The meiotic spindle pole body may promote membrane assembly by stimulating the activity of a Rab GTPase.